vivaMETABOLITE

Metabolism is the set of cellular mechanisms that generate energy from our food and environment to power every single cell in the body. It is as unique as your fingerprint and can be affected by factors such as age, body composition, hormone function, physical activity levels and diet 

... since all cells in the body require energy to function, metabolic health is foundational for overall health and well-being 

... when these energy-producing pathways run smoothly, we have optimal metabolic health 

... so understanding your metabolism – how your body produces and consumes energy – is a key to improving your overall health and wellbeing.

vivaLABS undertakes metabolomics assessment on your first morning urine.   We use LCMS/MS/MS (Liquid chromatography mass spectrometry) techniques to identify the individual chemical metabolites that present in your sample.  This allows for a large-scale assessment of your metabolites to identify what is present, at what quantities and their interactions within a biological system known as the metabolome.

vivaLAB metabolic nutrient deficiency testing focuses organic acids, which are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. on   Identifying these metabolic blocks may allow for treatment nutritionally allowing individual tailoring of interventions that maximise patient responses and lead to improved patient outcomes.

1. Methylation sufficiency 
Methylation sufficiency is a crucial biochemical process in the body which is vital for DNA repair and expression, hormone regulation, detoxification, and immune system function. Methylation plays a key role in the synthesis of neurotransmitters, affecting mood and cognitive functions, and is also involved in the metabolism of homocysteine, an amino acid linked with cardiovascular disease when present in high levels. The importance of maintaining methylation sufficiency lies in its impact on overall health and prevention of various conditions, including cardiovascular diseases, certain cancers, neurological disorders, and complications during pregnancy. Factors such as diet, lifestyle, and genetic predispositions can influence methylation efficiency, pointing to the need for nutritional support with methyl donors like folate, vitamin B12, and methionine, especially in individuals with genetic variations affecting methylation pathways, to ensure optimal health and well-being.

2. Functional vitamins and minerals 
Play a pivotal role in maintaining and enhancing human health, acting as essential nutrients that our bodies need to function correctly. These micronutrients support a myriad of bodily functions, including bone health, immune response, and energy production. Vitamin D is crucial for calcium absorption, vital for bone density and strength, while vitamin C is a key player in immune system function and skin health through its role in collagen production. Minerals like iron are fundamental for oxygen transport in the blood, supporting energy levels and cognitive function. Vitamins and minerals are needed in smaller amounts, yet their impact on our health is profound. A balanced intake of these nutrients is essential for preventing deficiencies, supporting overall well-being, and reducing the risk of chronic diseases

3. Amino Acid insufficiencies 
Amino acid insufficiencies can significantly impact health and well-being, given amino acids' critical roles as the building blocks of proteins. Proteins, in turn, are essential for virtually every bodily function, including tissue repair, enzyme and hormone synthesis, and immune system function. Insufficient intake or absorption of essential amino acids can lead to symptoms such as fatigue, muscle weakness, and compromised immune response. Over time, amino acid deficiencies can result in more severe health issues, including muscle wasting, and difficulties in managing stress and recovering from illnesses. Amino acids are pivotal in maintaining muscle mass, supporting metabolic processes, and ensuring the overall homeostasis of the body. A well-balanced diet rich in protein sources is vital for supplying all necessary amino acids and supporting optimal health.

4. Oxidative damage and antioxidant need 
Oxidative damage is a critical factor in the ageing process and the development of many chronic diseases, occurring when there's an imbalance between free radicals and antioxidants in the body. Free radicals are highly reactive molecules generated during normal cellular processes or through external sources like pollution and UV exposure. Antioxidants play a crucial defensive role by neutralizing free radicals, thereby preventing the chain reactions that lead to cellular damage. The importance of antioxidants lies in their capacity to protect the body from the effects of oxidative stress, which is linked to a range of conditions including heart disease, cancer, and neurodegenerative disorders like Alzheimer's disease. A diet rich in antioxidants can support the body's natural defence system contributing to overall health and longevity. 

5. Mitochondrial energy production 
Mitochondrial energy production, known as cellular respiration, is a fundamental process for life, serving as the powerhouse of the cell. Mitochondria convert nutrients from the food we eat into adenosine triphosphate (ATP), the energy currency of cells, through a complex series of reactions. The importance of mitochondrial energy production extends beyond mere energy supply. It is also intricately linked to cellular health, aging, and the body's ability to respond to stress and repair damage. Dysfunctions in mitochondrial energy production are associated with a wide range of diseases, including neurodegenerative disorders like Parkinson's and Alzheimer's, cardiovascular diseases, and diabetes. Maintaining mitochondrial health is crucial for overall well-being, highlighting the need for lifestyle choices that support mitochondrial function, such as regular exercise, a balanced diet rich in nutrients, and avoiding exposure to toxins. 

6. Microbiome dysbiosis markers 
Dysbiosis markers, including signs of bacterial and yeast overgrowth, are critical indicators of an imbalanced microbiome, which can have profound effects on health and disease. The human gut hosts a complex community of microorganisms that play essential roles in digestion, immune function, and even mood regulation. When the delicate balance among these microorganisms is disrupted, harmful bacteria or yeast can proliferate, leading to conditions such as small intestinal bacterial overgrowth (SIBO) or Candida overgrowth. These imbalances can manifest through a variety of symptoms, including digestive issues, fatigue, skin problems, and altered immune responses. The importance of identifying and addressing dysbiosis lies in its potential to contribute to a wide range of health issues, from irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) to systemic conditions like autoimmune diseases and metabolic syndrome. Recognizing dysbiosis markers is a crucial step in diagnosing underlying imbalances and guiding interventions, such as dietary changes, probiotics, or antimicrobial treatments, to restore a healthy microbiome and improve overall health.

The vivaLAB facilities for metabolomics testing have NATA ISO 15189: Requirements for Quality and Competence in Medical Laboratories accreditation. As a consumer, you can trust that your data is consistent and completely private.