vivaOSTEO

The science behind the bacterials strains:

1. Lactobacillus paracasei 8700:2: Known for its ability to modulate the immune system, this strain influences the osteo-immune microenvironment. It reduces bone resorption by decreasing inflammatory cytokines such as TNFα and IL1β, which can lead to bone loss. By maintaining a healthy balance in the gut microbiota, L. paracasei 8700:2 supports overall bone density [1][2]. Studies have also shown that probiotics, like those in vivaOSTEO, can inhibit cartilage damage and slow the progression of osteoarthritis [7
2. Lactobacillus plantarum HEAL9 & HEAL19: These strains positively affect bone mineral density (BMD), particularly in populations at risk for osteoporosis, such as postmenopausal women. Research indicates that L. plantarum promotes a favorable environment for bone regeneration by modulating inflammatory markers and supporting osteogenic processes [3]. These strains enhance the production of short-chain fatty acids (SCFAs) in the gut, which are crucial for improving calcium absorption—a vital factor for bone health [4][5][6].

Benefits of the product:

Improvement in Bone Mineral Density (BMD): 
Studies have demonstrated that probiotics, similar to those found in vivaOSTEO, can significantly increase BMD in models of postmenopausal osteoporosis, suggesting that vivaOSTEO may help prevent bone loss associated with aging, particularly in at-risk populations like postmenopausal women [3][10]. 

Modulation of Osteo-Immune Environment: 
Probiotics have been shown to modulate the balance of inflammatory cytokines, critical in bone remodeling. By reducing markers such as TNFα and IL1β, the probiotics in vivaOSTEO create a more favorable environment for bone regeneration, supporting overall bone health [1][2]. Additionally, they offer protection against conditions like osteoarthritis by inhibiting cartilage damage and disease progression [7]. 

Protection Against Bone Loss: 
Research indicates that probiotics can partially protect against bone loss induced by ovariectomy or castration, which are models for postmenopausal and hypogonadal osteoporosis, respectively. These findings suggest that vivaOSTEO could be particularly beneficial for maintaining bone health in individuals undergoing hormonal changes that predispose them to bone loss [4][5][6][9]. 

References: 

1. Chen, K. (2024). Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation. Journal of Translational Medicine, 22(1). https://doi.org/10.1186/s12967-024-05261-0
2. Yang, S. (2024). Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the mir-21a-5p/pdcd4/nf-κb pathway. Journal of Nanobiotechnology, 22(1). https://doi.org/10.1186/s12951-024-02352-4 
3. Kim, M., Bok, M., Lim, H., & Yang, W. (2023). An integrative study on the inhibition of bone loss via osteo-f based on network pharmacology, experimental verification, and clinical trials in postmenopausal women. Cells, 12(15), 1992. https://doi.org/10.3390/cells12151992 
4. Ohlsson, C., Lawenius, L., Andersson, A., Gustafsson, K., Wu, J., Lagerquist, M., Movérare-Skrtic, S., Islander, U., & Sjögren, K. (2021). Mild stimulatory effect of a probiotic mix on bone mass when treatment is initiated 1.5 weeks after ovariectomy in mice. American Journal of Physiology-Endocrinology and Metabolism, 320(3), E591-E597. https://doi.org/10.1152/ajpendo.00383.2020
5. Lawenius, L., Colldén, H., Gustafsson, K. L., Wu, J., Grahnemo, L., Vandenput, L., Ohlsson, C., & Sjögren, K. (2022). A probiotic mix partially protects against castration-induced bone loss in male mice. Journal of Endocrinology, 254(2), 91-101. https://doi.org/10.1530/JOE-21-0357 
6. Ohlsson, C., Engdahl, C., Fåk, F., Andersson, A., Windahl, S. H., Farman, H. H., Movérare-Skrtic, S., Islander, U., & Sjögren, K. (2014). Probiotics protect mice from ovariectomy-induced cortical bone loss. PLoS One, 9(3), e92368. https://doi.org/10.1371/journal.pone.0092368
7. Sophocleous, A., Azfer, A., Huesa, C., Stylianou, E., & Ralston, S. H. (2023). Probiotics inhibit cartilage damage and progression of osteoarthritis in mice. Calcified Tissue International, 112(1), 66-73. https://doi.org/10.1007/s00223-022-00993-3 
8. Liu, J., Yu, F., Sun, Y., Jiang, B., Zhang, W., Yang, J., … & Liu, S. (2015). Concise reviews: characteristics and potential applications of human dental tissue-derived mesenchymal stem cells. The International Journal of Cell Cloning, 33(3), 627-638. https://doi.org/10.1002/stem.1909 
9. Jansson, P.-A., Curiac, D., Lazou Ahrén, I., Hansson, F., Martinsson Niskanen, T., Sjögren, K., & Ohlsson, C. (2019). Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: A randomised, double-blind, placebo-controlled, multicentre trial. The Lancet Rheumatology, 1(3), e154-e162. https://doi.org/10.1016/S2665-9913(19)30065-0
10. Gianoudis, J., Bailey, C., Ebeling, P., Nowson, C., Sanders, K., Hill, K., … & Daly, R. (2013). Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: a community-based randomized controlled trial. Journal of Bone and Mineral Research, 29(1), 182-191. https://doi.org/10.1002/jbmr.2014

Always read the label. Follow the directions for use. If symptoms persist, consult your healthcare professional. Vitamin supplements should not replace a balanced diet. If you have any pre-existing conditions, or are on any medications always talk to your health professional before use. Store your daily packs below 25°C in a cool, dry place, away from humidity and direct sunlight.